Smoke plumes rise following missile strikes in Tehran.
Image: Atta Kenare / AFP
Iran "will not negotiate with the United States", Ali Larijani, the powerful head of Tehran's Supreme National Security Council, said on Monday.
In a post on X, Larijani denied media reports that Iranian officials had sought to initiate talks with the Trump administration following a wave of US-Israeli strikes on Iran over the weekend, which came after Tehran and Washington held nuclear negotiations.
He added that Trump's "delusional fantasies" have plunged the Middle East into chaos.
"Trump plunged the region into chaos with his 'delusional fantasies' and now fears more American troop casualties," Larijani wrote on X, following a wave of US-Israeli strikes on Iran.
Meanwhile, Israel and Hezbollah have traded fire, while President Donald Trump vowed to avenge the deaths of US service members and said the war with Iran could last for weeks.
The European Union has warned of the cost to the Middle East of a long war, and said it was reinforcing its naval mission in the Red Sea.
Gulf states vowed to defend themselves against Iranian attacks, while seven people were injured in Jerusalem after a missile barrage.
Here are the latest developments:
Israel said it was striking Hezbollah targets across Lebanon after the militant group said it had launched rockets and drones at Israel.
A military statement said that "in response to Hezbollah's projectile fire toward the State of Israel", Israeli forces had "begun striking targets of the Hezbollah terrorist organisation across Lebanon".
Mourners gather during a memorial rally held by supporters of Lebanon’s Hezbollah movement a day after Iran’s supreme leader was assassinated. Hezbollah has vowed to confront the US and Israel over their strikes on the group's key backer Iran.
Image: Anwar Amro / AFP
The Israeli military told residents of about 50 towns and villages in Lebanon to evacuate, warning of imminent attacks against Hezbollah militants.
The United States and its Arab allies condemned Iran for launching a wave of strikes on Gulf states hosting US troops.
"The targeting of civilians and of countries not engaged in hostilities is reckless and destabilizing behavior," the US State Department said in a joint statement with Bahrain, Jordan, Kuwait, Qatar, Saudi Arabia and the United Arab Emirates.
The Israeli military said it launched "large-scale strikes" on Tehran two days after the start of a US-Israeli campaign against Iran.
"The Israeli Air Force... has begun an additional wave of strikes against the Iranian terror regime at the heart of Tehran," the military said in a statement.
Trump told The New York Times on Sunday that he had "three very good choices" for who could lead Iran, but he did not name them.
"I won't be revealing them now. Let’s get the job done first," he said.
Pentagon chief Pete Hegseth will hold a press conference on Monday morning about the joint US-Israeli military campaign against Iran, the first by a senior official since strikes began on Saturday.
Dan Caine, the chairman of the joint chiefs of staff, will also take part, the Pentagon said.
Top US officials, including Secretary of State Marco Rubio, will make the case Tuesday to Congress for the attack on Iran.
Rubio, Hegseth, CIA Director John Ratcliffe and military chief Caine "will brief the full membership of both chambers of Congress," White House spokesman Dylan Johnson said.
British forces are responding to a suspected drone strike at its military base in Cyprus, the defence ministry said Monday, with no casualties reported.
The strike hit the RAF Akrotiri base at midnight, said the ministry, adding that its forces were handling a "live situation".
The incident came as Britain agreed on Sunday to allow the United States to use British military bases to fire "defensive" strikes at Iranian missile systems.
Container shipping company Maersk said it was halting passage through the Suez Canal and the Strait of Hormuz for "safety" reasons.
The Danish group was the latest of several shipping groups to make similar announcements after Iran's Revolutionary Guards declared the strait closed on Saturday.
Gulf states vowed to defend themselves against Iranian attacks, including by "responding to the aggression" if need be, after the Gulf Cooperation Council convened via video-link to formulate a unified response.
Seven people were injured in the Jerusalem area following the latest salvo of missiles fired from Iran, Israeli firefighters said.
The EU is to reinforce its naval mission in the Red Sea with additional vessels as Iran's retaliation to US-Israeli strikes threatens maritime traffic, a European diplomat said.
Two new French ships will join the EU's Aspides mission, bringing to five the number of warships taking part, the diplomat told AFP.
Trump vowed to avenge the deaths of three US soldiers killed during US operations against Iran, while warning that more casualties were likely.
The US president also called on Iranians to rise up, saying "America is with you," and warned the country's Revolutionary Guards to surrender or face "certain death."
Trump said he envisaged a four-week military operation against Iran, where US and Israeli strikes have killed the country's supreme leader and crippled its defence capabilities.
"It's always been a four-week process. We figured it will be four weeks or so," he told British newspaper the Daily Mail during a round of interviews.
"As strong as it is, it's a big country, it'll take four weeks -- or less," Trump said.
The US military announced it had destroyed the Revolutionary Guard (IRGC) headquarters.
"America has the most powerful military on earth, and the IRGC no longer has a headquarters," the US Central Command, or CENTCOM, said in a statement, adding that the strike had occurred on Saturday.
Israel's military, meanwhile, said it "struck dozens of the regime's military command centres, including headquarters belonging to the Islamic Revolutionary Guard Corps (IRGC), intelligence headquarters, IRGC Air Force command centres, and internal security headquarters."
The EU's top diplomat warned that the Middle East "stands to lose greatly from any drawn-out war", urging Iran to refrain from indiscriminate attacks in retaliation for US-Israeli strikes.
"The events unfolding in Iran must not lead to an escalation that could threaten the Middle East, Europe and beyond, with unpredictable consequences," Kaja Kallas said, speaking on behalf of the EU's 27 nations after an emergency meeting of foreign ministers.
Iranian media reported that a police station in a city on the outskirts of Tehran had been hit, killing an unspecified number of people, with others reportedly trapped under debris.
"According to initial reports, a number of citizens were martyred and some were trapped under the rubble," the Tasnim news agency reported.
Iranian news agency ISNA reported that Gandhi hospital in northern Tehran had been targeted by strikes.
The Fars and Mizan agencies published a video, presented as being from inside the facility, showing debris on the floor among wheelchairs.
AFP